| Venerdi 10/12/21 | Inhulets | 2 - 1 | FK Desna Chernihiv | |
|---|---|---|---|---|
| Domenica 05/12/21 | FK Desna Chernihiv | 3 - 3 | Mariupol | |
| Sabato 27/11/21 | Chernomorets Odessa | 0 - 1 | FK Desna Chernihiv | |
| Domenica 21/11/21 | FK Desna Chernihiv | 0 - 1 | Kolos Kovalyovka | |
| Domenica 07/11/21 | FK Lviv | 0 - 2 | FK Desna Chernihiv | |
| Sabato 30/10/21 | Shakhtar Donetsk | 4 - 1 | FK Desna Chernihiv | |
| Venerdi 22/10/21 | FK Desna Chernihiv | 1 - 1 | Oleksandria | |
| Domenica 17/10/21 | Minaj | 0 - 0 | FK Desna Chernihiv | |
| Domenica 03/10/21 | Zorya | 2 - 0 | FK Desna Chernihiv | |
| Domenica 26/09/21 | FK Desna Chernihiv | 1 - 2 | Metalist Kharkiv | |
| Venerdi 17/09/21 | FK Desna Chernihiv | 1 - 0 | Rukh Lviv | |
| Domenica 12/09/21 | Vorskla Poltava | 2 - 2 | FK Desna Chernihiv | |
| Domenica 29/08/21 | FK Desna Chernihiv | 0 - 4 | Veres Rivne | |
| Domenica 22/08/21 | Dynamo Kiev | 4 - 0 | FK Desna Chernihiv | |
| Sabato 14/08/21 | FK Desna Chernihiv | 2 - 1 | SK Dnipro-1 | |
| Lunedi 09/08/21 | FK Desna Chernihiv | 2 - 0 | Inhulets | |
| Domenica 01/08/21 | Mariupol | 1 - 2 | FK Desna Chernihiv | |
| Domenica 25/07/21 | FK Desna Chernihiv | 3 - 0 | Chernomorets Odessa | |
| Domenica 09/05/21 | Mariupol | 4 - 1 | FK Desna Chernihiv | |
| Mercoledi 05/05/21 | Vorskla Poltava | 1 - 1 | FK Desna Chernihiv |