Domenica 06/03/22 OFI Crete 2 - 0 Apollon Smirnis
Lunedi 28/02/22 Apollon Smirnis 0 - 2 Atromitos
Mercoledi 23/02/22 Ionikos 4 - 0 Apollon Smirnis
Domenica 20/02/22 Lamia 1 - 2 Apollon Smirnis
Mercoledi 16/02/22 Apollon Smirnis 0 - 3 Panathinaikos
Sabato 12/02/22 Apollon Smirnis 0 - 0 Panaitolikos Argos
Domenica 06/02/22 Aek Atene 3 - 0 Apollon Smirnis
Mercoledi 02/02/22 Apollon Smirnis 0 - 2 Paok
Domenica 30/01/22 PAS Giannina 2 - 0 Apollon Smirnis
Lunedi 24/01/22 Asteras Tripolis 1 - 0 Apollon Smirnis
Mercoledi 19/01/22 Volos NFC 1 - 0 Apollon Smirnis
Sabato 15/01/22 Apollon Smirnis 0 - 0 Aris
Mercoledi 12/01/22 Apollon Smirnis 0 - 3 OFI Crete
Mercoledi 05/01/22 Apollon Smirnis 0 - 0 Olympiakos Piraeus
Sabato 04/12/21 Atromitos 4 - 1 Apollon Smirnis
Sabato 27/11/21 Apollon Smirnis 0 - 0 Lamia
Domenica 21/11/21 Panaitolikos Argos 1 - 0 Apollon Smirnis
Sabato 06/11/21 Apollon Smirnis 2 - 2 Aek Atene
Sabato 30/10/21 Paok 4 - 1 Apollon Smirnis
Sabato 23/10/21 Apollon Smirnis 1 - 0 PAS Giannina